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Always refer to Cobalex 2000 Injection Directions for Use for full instructions, use rates, application and critical comments

Type I immediate hypersensitivity reaction to cyanocobalamin but not hydroxycobalamin

1 Mecobalamin 50 mg or placebo was administered intramuscularly twice weekly for 16 weeks to 130 ALS patients who had suffered from ALS for less than one year, were classified as definite, probable, or probable-laboratory supported according to the Updated Awaji Criteria, had an ALS severity rating of grade 1 or 2, had a decrease of 1 or 2 points in the total score on the Revised ALS Functional Rating Scale-Revised (ALSFRS-R) 12 weeks prior to administration, and had a forced vital capacity (%FVC) of more than 60%

Third, they support the safety of repeated treatment cycles, as prior exposure does not appear to sensitize the immune system